Kev ua haujlwm ntawm ceramic insulator yog kev taw qhia

Kev ua haujlwm ntawm insulator yog kev taw qhia, uas muaj nyob rau hauv kev sim ntawm cov txiv hmab txiv ntoo ya. Kev ntxig ntawm transposon Gypsy mus rau hauv qhov chaw daj y ntawm Drosophila (D. melanogaster) yuav ua rau cov noob Y hauv qee cov ntaub so ntswg, tab sis cov noob Y tseem ua haujlwm hauv qee cov ntaub so ntswg. Yog vim li cas yog hais tias muaj ib tug insulator ib theem zuj zus ntawm ib kawg ntawm lub transposon gypsy. Thaum Gypsy muab tso rau ntawm qhov chaw sib txawv ntawm qhov chaw, nws muaj qhov sib txawv ntawm cov kev ua ntawm noob. Qhov no yog vim qhov kev ua ntawm Y noob yog tswj los ntawm plaub qhov kev txhim kho. Thaum lub insulator yog ntxig rau ntawm tus txhawb nqa, nws thaiv qhov kev ua ntawm Y noob nyob rau hauv tis hniav thiab lub cev cuticle cov ntaub so ntswg (los ntawm cov upstream enhancer), tab sis tsis thaiv cov kev qhia ntawm Y gene nyob rau hauv bristles thiab deb claws ntaub so ntswg (los ntawm tus downstream enhancer). Txij li thaum qee qhov kev txhim kho nyob rau sab saud thiab qee qhov qis ntawm tus txhawb nqa, cov nyhuv ntawm cov insulator tsis nyob ntawm qhov txheeb ze ntawm lub insulator thiab tus txhawb nqa. Yog li ntawd, vim li cas rau lub directionality ntawm insulator nyhuv tsis tau to taub tiag tiag. Tam sim no, nws tau pom tias ob loci cuam tshuam rau kev ua haujlwm ntawm insulators los ntawm trans activation. Cov nucleoprotein encoded los ntawm noob S2J (HW) paub txog lub insulator, thiab lub insulator muaj rwb thaiv tsev nyhuv tsuas yog tom qab nws tau ua ke nrog nws. Thaum cov noob tau hloov pauv, txawm hais tias ib qho insulator tau muab tso rau hauv Y locus, nws poob nws cov nyhuv insulating, thiab y tau qhia nyob rau hauv tag nrho cov ntaub so ntswg. Lwm qhov chaw yog mod (MDG 4). Tom qab kev hloov pauv ntawm cov noob no, nws cov txiaj ntsig tsuas yog rov qab rau su (HW), uas yog, cov mutants no txhim kho cov nyhuv rwb thaiv tsev, yog li ntawd cov nyhuv rwb thaiv tsev ntawm insulator tsis muaj kev taw qhia thiab nthuav dav, uas yog, thaiv cov nyhuv ntawm kev txhim kho. ntawm ob sab ntug dej thiab sab qab teb. Ib qho kev piav qhia yog tias Su (HW) ua ntej khi rau insulator DNA kom insulator muaj cov nyhuv rwb thaiv tsev. Kev sib xyaw ua ke ntawm mod (MDG4) thiab su (HW) ua rau lub rwb thaiv tsev poob cov nyhuv rwb thaiv tsev; Lub abrupt mod (MDG4) tsis tuaj yeem ua ke nrog Su (HW), yog li cov insulator txhim kho cov nyhuv rwb thaiv tsev.